Deciem Hylamide SubQ Skin Serum Review – the ultimate anti-aging serum? | Doctors Review


To be honest, I don’t use purely hydrating serums anymore. They might be fine in your twenties, but for someone like me, the Hylamide SubQ Skin Serum is a much better pick. (More info: The best skincare to use in your 20s)
You see, hydration is really important, and it still is at age 43, but I want something with a little more oomph without needing to layer three different serums each morning, I just don’t have the time or patience for that.


Deciem Hylamide SubQ Skin Review
Hylamide SubQ Skin


The Hylamide SubQ Skin Serum is named “the ultimate anti-aging serum” in reviews on here, so I was intrigued. But is it really that good?



What the Hylamide SubQ Skin Serum claims

For multi-depth rehydration and reduction in the look of lines and irregularities


Facts about the Hylamide SubQ Skin Serum

Prize and size

One dropper bottle, made of frosted glass, contains 30 ml and is available for 22 $ on the website here. It is part of the Hylamide Core Series, has a pH of 5,5-6,5 and is vegan.


Texture and smell

The serum has a slightly thicker texture that spreads easily and has no scent. Like most serums that are high in Hyaluronic Acid it leaves behind a minimal stickiness, but way less than others and only for around a minute.

(More info: Hyaluronic Acid in skincare – More than a humectant?)


Close up of the Hylamide SubQ Skin Serum
Close up of the Hylamide SubQ Skin Serum


How to use the Hylamide SubQ Skin Serum

Morning, evening, or both are possible places for it in your routine, and all of that works well. I like to apply it to slightly damp skin, either directly after cleansing or after toner, should I use one, and then follow up with moisturizer at night or my sunscreen in the mornings. It contains peptides, which prefer a less acidic environment, so pairing it with Acids or Ascorbic Acid with a low pH might reduce the effects.

(More info: Everything you need to know about peptides in skincare)


Ingredients of the Hylamide SubQ Skin Serum

Aqua (Water) solv, Glycerin sii|h 0 0, Hydrolyzed Yeast Extract h, Pentylene Glycol solv|h, Tamarindus Indica Seed Gum h|vc, Sodium Hyaluronate Crosspolymer sii|aox|h, Palmitoyl Tripeptide-38 cci, Myristoyl Nonapeptide-3 cci, Copper Lysinate/Prolinate cci, Methylglucoside Phosphate cci, Hydrolyzed Sodium Hyaluronate h, Sodium Hyaluronate sii|h 0 0, Ahnfeltia Concinna Extract vc, Saccharide Isomerate h, Polyglucuronic Acid h, Lactobacillus/Eriodictyon Californicum Ferment Extract h, Pseudoalteromonas Ferment Extract so|h, Phospholipids sii|emo, Lecithin emo|emu, Hydroxypropyl Cyclodextrin , Cetyl Hydroxyethylcellulose vc, Polyacrylate Crosspolymer-6 vc, Hexylene Glycol solv|emu|perf|surf 01 02, Salicylic Acid exf|aacne|so|pres, Citric Acid buff, Sodium Citrate chel|buff, Sodium Hydroxide buff, Trisodium Ethylenediamine Disuccinate chel, Ethoxydiglycol solv|h|perf 0 0, Leuconostoc/Radish Root Ferment Filtrate amic|pres, Sodium Benzoate pres, Potassium Sorbate pres, Ethylhexylglycerin pres, Caprylyl Glycol h|emo, Phenoxyethanol pres, Chlorphenesin pres|amic

Hover the mouse over an ingredient for short explanation. Read more on INCIDecoder.
Humectants used are Glycerin, several molecular weights of Hyaluronic Acid as well as a complex called Optim Hyal, which is Hydrolyzed Yeast Extract and Polyglucuronic Acid and apparently stimulates the skins own Hyaluronic Acid production for a more lasting effect.
Then there are several peptides, claiming to improve collagen production, and another complex called Neodermyl which, according to the manufacturer, not only stimulates collagen production, but also elastin production – that would be an industry first. There are also fermented ingredients and, some eagle-eyed viewers might have spotted it, Salicylic Acid. The latter one comes way after the peptides in the ingredient list, which are usually used at very low concentrations, so I don’t think you get an actual relevant BHA-effect from this one.

(More info: How to read the ingredient lists in cosmetics)


Does it live up to its claims?


It is hydrating with a lovely texture and plumps up the skin, making fine lines less noticeable.


How does it compare to…


THE INKEY LIST Hyaluronic Acid
THE INKEY LIST Hyaluronic Acid – a budget alternative?


The Inkey List Hyaluronic Acid

Similar in texture and in the main humectants, The Inkey List contains other peptides and none of the new complexes. If these potentially effective ingredients are worth paying three times the price is a very personal decision.

You can read my full review of The Inkey List Hyaluronic Acid here.


NIOD Copper Amino Isolate Serum 3 Review
NIOD Copper Amino Isolate Serum 3


NIOD Copper Amino Isolate 3

This is a recent discovery for me, and one that also comes from the Deciem brand. Copper Peptides do have the most research out of all peptides, and despite not having as many humectants I find the NIOD one hydrating enough for my skin. It is at 70 € much more expensive though, so again you need to see if it is worth the investment for you.

You can read my full review of the NIOD Copper Amino Isolate 3 here


Would I repurchase and which skin types do I recommend the Hylamide SubQ Skin Serum to?

Although I enjoy it and will continue to use it, I don’t think I will repurchase. When it comes to peptides, it is copper peptides for me, and for the new complexes used – I just didn’t see a difference in my own skin that made me a believer. Yes, that is anecdotal evidence and changes might be so subtle now that it would take several years for them to be noticeable, but that is just how I feel.
As far as skin types is concerned, this will work for everyone that doesn’t react to low molecular weight Hyaluronic Acid, but due to the added peptides and complexes is probably aimed at more mature skin.


Hylamide SubQ Skin Serum Review
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